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Group: Ghribi Lab, Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA

Key members: Othman Ghribi, Kimberly hammer, Shaneabbas Raza, Jessica Warns

Contact: Othman Ghribi: Othman.ghribi@med.und.edu

 

Research activities: We are interested in determining the potential role of the oxysterols 27-hydroxycholesterol and 24-hydroxycholesterol in the pathogenesis of both central nervous diseases, such as Alzheimer’s disease and Parkinson’s disease, and peripheral system diseases such as colorectal and prostate cancers. The focus of our research is to characterize the signaling pathways including LXR and ER signaling in vitro and in vivo models that can be targeted using in vitro and in vivo model to reduce the progression of neurodegenerative and cancer diseases.

 

Key papers related to ENOR:

1: Gongol B, Marin TL, Jeppson JD, Mayagoitia K, Shin S, Sanchez N, Kirsch WM,

Vinters HV, Wilson CG, Ghribi O, Soriano S. Cellular hormetic response to

27-hydroxycholesterol promotes neuroprotection through AICD induction of MAST4

abundance and kinase activity. Sci Rep. 2017 Oct 24;7(1):13898. doi:

10.1038/s41598-017-13933-9.

 

2: Marwarha G, Raza S, Hammer K, Ghribi O. 27-hydroxycholesterol: A novel player

in molecular carcinogenesis of breast and prostate cancer. Chem Phys Lipids. 2017

Oct;207(Pt B):108-126. doi: 10.1016/j.chemphyslip.2017.05.012.

 

3: Raza S, Meyer M, Goodyear C, Hammer KDP, Guo B, Ghribi O. The cholesterol

metabolite 27-hydroxycholesterol stimulates cell proliferation via ERβ in

prostate cancer cells. Cancer Cell Int. 2017 May 11;17:52. doi:

10.1186/s12935-017-0422-x.

 

4: Marwarha G, Ghribi O. Does the oxysterol 27-hydroxycholesterol underlie

Alzheimer's disease-Parkinson's disease overlap? Exp Gerontol. 2015 Aug;68:13-8.

doi: 10.1016/j.exger.2014.09.013. Epub 2014 Sep 28. Review. P