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Team: Environment-Spermatogenesis-Pathophysiology and Inheritance.

Inserm U1103, CNRS UMR 6293, Université Clermont Auvergne, Clermont-Ferrand, France

 

Permanent Members:

Claude Beaudoin, Pr

Françoise Caira, MCU

Hélène Holota, IE CNRS

Angélique de Haze, Ass. Ingenieure UCA

Jean-Paul Saru, Tech. UCA

David H Volle, DR2 Inserm (Team leader).

Contacts:   David Volle, david.volle@insem.fr

 

 

Research activities:

Our themes of research are focused on stem cells, metabolism, testis physiology, the understanding of the spermatogenesis process, cell signaling, epigenetic, environmental exposure as well as germ cell cancer (website: https://www.gred-clermont.fr/directory/team/fr/equipe-13-environnement-spermatogenese-pathophysiologie-et-heredite/).

Since 2010, we have focused our efforts on decrypting the molecular mechanisms underlying the links between bile acid metabolism and impaired male fertility. Our studies are mainly focused on understanding the roles of the bile acid receptors FXRalpha and TGR5 in testis.

 

Key papers related to ENOR:

 

Bile acids, roles in integrative physiology and pathophysiology.

Volle DH.

Mol Aspects Med. 2017 Aug;56:1. doi: 10.1016/j.mam.2017.07.001. No abstract available.

PMID: 28711135

 

The Bile Acid Nuclear Receptor FXRα Is a Critical Regulator of Mouse Germ Cell Fate.

Martinot E, Sèdes L, Baptissart M, Holota H, Rouaisnel B, Damon-Soubeyrand C, De Haze A, Saru JP, Thibault-Carpentier C, Keime C, Lobaccaro JA, Baron S, Benoit G, Caira F, Beaudoin C, Volle DH.

Stem Cell Reports. 2017 Jul 11;9(1):315-328. doi: 10.1016/j.stemcr.2017.05.036. Epub 2017 Jun 29.

PMID: 28669602 Free PMC Article

 

Bile acids and male fertility: From mouse to human?

Sèdes L, Martinot E, Baptissart M, Baron S, Caira F, Beaudoin C, Volle DH.

Mol Aspects Med. 2017 Aug;56:101-109. doi: 10.1016/j.mam.2017.05.004. Epub 2017 May 16. Review.

PMID: 28511935

 

Bile acid homeostasis controls CAR signaling pathways in mouse testis through FXRalpha.

Martinot E, Baptissart M, Véga A, Sèdes L, Rouaisnel B, Vaz F, Saru JP, de Haze A, Baron S, Caira F, Beaudoin C, Volle DH.

Sci Rep. 2017 Feb 9;7:42182. doi: 10.1038/srep42182.

PMID: 28181583 Free PMC Article

 

Bile acids and their receptors.

Martinot E, Sèdes L, Baptissart M, Lobaccaro JM, Caira F, Beaudoin C, Volle DH.

Mol Aspects Med. 2017 Aug;56:2-9. doi: 10.1016/j.mam.2017.01.006. Epub 2017 Jan 30. Review.

PMID: 28153453

 

Nuclear receptors as pharmacological targets, where are we now?

Volle DH.

Cell Mol Life Sci. 2016 Oct;73(20):3777-80. doi: 10.1007/s00018-016-2327-6. Epub 2016 Aug 9. Review.

PMID: 27506618

 

Bile acid-FXRα pathways regulate male sexual maturation in mice.

Baptissart M, Martinot E, Vega A, Sédes L, Rouaisnel B, de Haze A, Baron S, Schoonjans K, Caira F, Volle DH.

Oncotarget. 2016 Apr 12;7(15):19468-82. doi: 10.18632/oncotarget.7153.

PMID: 26848619 Free PMC Article

 

Bile Acid Alters Male Mouse Fertility in Metabolic Syndrome Context.

Vega A, Martinot E, Baptissart M, De Haze A, Vaz F, Kulik W, Damon-Soubeyrand C, Baron S, Caira F, Volle DH.

PLoS One. 2015 Oct 6;10(10):e0139946. doi: 10.1371/journal.pone.0139946. eCollection 2015.

PMID: 26439743 Free PMC Article

 

Identification of the link between the hypothalamo-pituitary axis and the testicular orphan nuclear receptor NR0B2 in adult male mice.

Vega A, Martinot E, Baptissart M, De Haze A, Saru JP, Baron S, Caira F, Schoonjans K, Lobaccaro JM, Volle DH.

Endocrinology. 2015 Feb;156(2):660-9. doi: 10.1210/en.2014-1418. Epub 2014 Nov 26.

PMID: 25426871

 

Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP.

Vega A, Baptissart M, Martinot E, Saru JP, Baron S, Schoonjans K, Volle DH.

Expert Opin Ther Targets. 2014 Dec;18(12):1367-76. doi: 10.1517/14728222.2014.964209. Epub 2014 Sep 29.

PMID: 25263461

 

 

Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice.

Baptissart M, Vega A, Martinot E, Pommier AJ, Houten SM, Marceau G, de Haze A, Baron S, Schoonjans K, Lobaccaro JM, Volle DH.

Hepatology. 2014 Sep;60(3):1054-65. doi: 10.1002/hep.27204.

PMID: 24798773

 

Liver X receptors interfere with the deleterious effect of diethylstilbestrol on testicular physiology.

Oumeddour A, Viennois E, Caira F, Decourbey C, Maqdasy S, Tahraoui A, Baron S, Volle DH, Lobaccaro JM.

Biochem Biophys Res Commun. 2014 Apr 11;446(3):656-62. doi: 10.1016/j.bbrc.2013.12.005. Epub 2013 Dec 11.

PMID: 24333430

 

 

Farnesoid X receptor alpha: a molecular link between bile acids and steroid signaling?

Baptissart M, Vega A, Martinot E, Baron S, Lobaccaro JM, Volle DH.

Cell Mol Life Sci. 2013 Dec;70(23):4511-26. doi: 10.1007/s00018-013-1387-0. Epub 2013 Jun 20. Review.

PMID: 23784309