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Group: Department of Agricultural and Food Sciences. Alma Mater Studiorum-Università di Bologna, Viale Fanin 40, 40127 Bologna, Italy

Key members: Maria Teresa Rodriguez Estrada, Dario Mercatante, Mara Mandrioli

Contact: Prof. Maria Teresa Rodriguez Estrada (


Research activities: the research interests of our group are focused on understanding the mechanisms behind sterol oxidation in model systems (i.e. standard mixtures and emulsions), and in food as related to dietary treatments, processing and storage conditions. The group is also interested in assessing the effects of electronic cigarette (e-cig) on sterol oxidation in biological samples from rats exposed to e-cig vaping. The research activity of the group is supported by a wide analytical expertise on method setting-up for the evaluation of sterol oxidation products by conventional (GC-FID, GC/MS, HPLC-ELSD) and innovative fast chromatographic techniques (Fast GC/MS), as well as for the evaluation of lipid composition (i.e. profiling of main lipid classes and fatty acids) and lipid oxidation parameters (i.e. volatile compounds, primary and secondary oxidation products).


Key papers related to ENOR:

Nutraceuticals and physical activity: Their role on oxysterols-mediated neurodegeneration. Malaguti, M., Cardenia, V., Rodriguez-Estrada, M.T., Hrelia, S. J Steroid Biochem Mol Biol. 2019, 193, Article number: 105430, 1-9.

The effect of electronic-cigarettes aerosol on rat brain lipid profile. Cardenia, V., Vivarelli, F., Cirillo, S., Paolini, M., Canistro, D., Rodriguez-Estrada, M.T. Biochimie. 2018, 153: 99-108.

Dietary effects of Raphanus sativus cv Sango on lipid and oxysterols accumulation in rat brain: A lipidomic study on a non-genetic obesity model. Cardenia, V., Vivarelli, F., Cirillo, S., Paolini, M., Rodriguez-Estrada, M.T., Canistro, D. Chem Phys Lipids. 2017, 207: 206-213.

Effect of broccoli extract enriched diet on liver cholesterol oxidation in rats subjected to exhaustive exercise. Cardenia, V., Rodriguez-Estrada, M.T., Lorenzini, A., Bandini, E., Angeloni, C., Hrelia, S., Malaguti, M. J Steroid Biochem Mol Biol. 2017, 169: 137-144.

Thermal oxidation of cholesterol: preliminary evaluation of 2-methyl-6-heptanone and 3-methylbutanal as volatile oxidation markers. Cardenia, V., Olivero, G., Rodriguez-Estrada, M.T. Steroids. 2015, 99: 161-171.

7-ketocholesterol as marker of cholesterol oxidation in model and food systems: when and how. Rodriguez-Estrada, M.T., Garcia-Llatas, G., Lagarda, M.J. Biochem Biophys Res Comm. 2014, 446: 792-797.

Cholesterol photosensitized oxidation in food and biological systems. Cardenia, V., Rodriguez-Estrada, M.T., Boselli, E., Lercker, G. Biochimie. 2013, 95: 473-481.

Analysis of cholesterol oxidation products by Fast gas chromatography/mass spectrometry. Cardenia, V., Rodriguez-Estrada, M.T., Baldacci, E., Savioli, S., Lercker, G. J Sep Sci. 2012, 35: 424-430.

Current and new insights on phytosterol oxides in plant sterol-enriched food Garcia-Llatas, G, Rodriguez-Estrada, M.T. Chem Phys Lipids. 2011, 164: 607-624.

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