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Team: Lipoproteins and Lipid transfer in sterile and septic inflammation (Lipness)
UMR1231, INSERM, Université de Bourgogne-Franche Comté, Dijon France

Permanent Staff involved in oxysterol research : 

Charles Thomas (MCU)
Thomas Gautier (CR INSERM)
Laurent Lagrost (DR INSERM)
Jean Paul Pais de Barros (IR INSERM)
Louise Ménégaut (PH_Post-Doc)
David Masson (PuPH)

Contact :

Research activities : Liver X receptors (LXRs) α and β are nuclear receptors activated by oxysterols. In contrast to cholesterol, the role of LXR in controlling fatty acid (FA) metabolism in macrophages has been overlooked. Nevertheless, recent works have contributed to change that view and it now appears that LXRs regulate all the facets of fatty metabolism in macrophages including exogenous FA uptake, de novo lipogenesis, PUFA synthesis and FA incorporation into glycerophospholipids. Moreover, recent studies suggest that modulation of FA metabolism by LXR is critical for the control of macrophage functions with potential consequences on the development of cardio-metabolic diseases. 
A main goal of our research program is to assess how modulation of FA metabolism by LXRs affects macrophage functions in the context of cardio-metabolic diseases (CMD) and more specifically during atherosclerosis.

Recent papers related to ENOR:

LPCAT3 deficiency in hematopoietic cells alters cholesterol and phospholipid homeostasis and promotes atherosclerosis. Thomas C, Jalil A, Magnani C, Ishibashi M, Queré R, Bourgeois T, Bergas V, Ménégaut L, Patoli D, Le Guern N, Labbé J, Gautier T, de Barros JPP, Lagrost L, Masson D. Atherosclerosis. 2018 Aug;275:409-418. doi: 10.1016/j.atherosclerosis.2018.05.023.


Fatty acid metabolism in macrophages: a target in cardio-metabolic diseases.Ménégaut L, Thomas C, Lagrost L, Masson D.Curr Opin Lipidol. 2017 Feb;28(1):19-26. doi: 10.1097/MOL.0000000000000370. Review.

Specific enrichment of 2-arachidonoyl-lysophosphatidylcholine in carotid atheroma plaque from type 2 diabetic patients. Ménégaut L, Masson D, Abello N, Denimal D, Truntzer C, Ducoroy P, Lagrost L, Pais de Barros JP, Athias A, Petit JM, Martin L, Steinmetz E, Kretz B. Atherosclerosis. 2016 Aug;251:339-347. doi: 10.1016/j.atherosclerosis.2016.05.004. Epub 2016 May


Liver X receptor activation promotes polyunsaturated fatty acid synthesis in macrophages: relevance in the context of atherosclerosis. Varin A, Thomas C, Ishibashi M, Ménégaut L, Gautier T, Trousson A, Bergas V, de Barros JP, Narce M, Lobaccaro JM, Lagrost L, Masson D. Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1357-65. doi: 10.1161/ATVBAHA.115.305539. Epub 2015 Apr 2.
Liver x receptor regulates arachidonic acid distribution and eicosanoid release in human macrophages: a key role for lysophosphatidylcholine acyltransferase 3. Ishibashi M, Varin A, Filomenko R, Lopez T, Athias A, Gambert P, Blache D, Thomas C, Gautier T, Lagrost L, Masson D. Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1171-9. doi: 10.1161/ATVBAHA.112.300812. Epub 2013 Apr 11.

Knock-down of the oxysterol receptor LXRα impairs cholesterol efflux in human primary macrophages: lack of compensation by LXRβ activation.Ishibashi M, Filomenko R, Rébé C, Chevriaux A, Varin A, Derangère V, Bessède G, Gambert P, Lagrost L, Masson D. Biochem Pharmacol. 2013 Jul 1;86(1):122-9. doi: 10.1016/j.bcp.2012.12.024. Epub 2013 Jan 9.

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